Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium
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چکیده
منابع مشابه
Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerob...
متن کاملVancomycin-resistant Enterococcus faecium colonization in children.
Nosocomial vancomycin-resistant Enterococcus (VRE) infections have been described in only small numbers of pediatric patients. In none of these studies were multivariate analyses performed to assess which factors were independent risk factors in these patients. In the present cohort study of patients admitted to our hematology/oncology unit, surveillance cultures revealed a colonization rate of...
متن کاملNatural history of colonization with vancomycin-resistant Enterococcus faecium.
OBJECTIVE To determine the incidence, duration, and genetic diversity of colonization with vancomycin-resistant Enterococcus faecium (VREF). SETTING Oncology unit of a 650-bed university hospital. METHODS Surveillance perianal swab cultures were performed on admission and weekly. The molecular relatedness of VREF isolates was determined by pulsed-field gel electrophoresis and by the hybridi...
متن کاملDaptomycin-reversible rifampicin resistance in vancomycin-resistant Enterococcus faecium.
OBJECTIVES In a previous study, we observed marked synergy between daptomycin and rifampicin against 73% of rifampicin-resistant, vancomycin-resistant Enterococcus faecium (VRE), with approximately 100-fold reductions in rifampicin MICs observed at one-eighth to one-fourth daptomycin MIC. The purpose of this study was to determine whether the synergy between daptomycin and rifampicin could be e...
متن کاملHigh-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2017
ISSN: 1931-3128
DOI: 10.1016/j.chom.2017.04.002